Just started warfarin a couple of months ago because of AF. I experience muscle cramps and joint pain that i didn't before warfarin. I mentioned it to the warfarin practitioner and she more or less dismissed the idea that it was caused by the warfarin. Paracetamol every 4hrs, 30-69mg codeine phosphate twice a day, warfarin. I've also been prescribed Diazepam 2mg for muscle cramps and spasms. I've been desperate to come off the warfarin as I'm experiencing horrible tight muscle pain in my groin and butt and would dearly love to take some ibuprofen. William C. Shiel Jr., MD, FACP, FACR. Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. I have been on coumadin for four months and am experiencing joint and muscle pain and stiffness. I am normally very flexible and have never experienced any type of joint or muscle pain before. Warfarin side effects: Watch for interactions. Although commonly used to treat blood clots, warfarin (Coumadin, Jantoven) can have dangerous side effects or interactions that can place you at risk of bleeding. Summary. Muscle pain is found among people who take Warfarin sodium, especially for people who are female, 60+ old , have been taking the drug for 1 - 6 months, also take medication Lipitor, and have High blood cholesterol. After my valve was replaced I had atrial fibrillation and was put on Warfarin. As well as muscle pain I began to get pains in my joints as well as muscles. I was on warfarin for 6 months and I went off it a month ago as the left leg showed to be dissolved and free of the clot. As I went off warfarin the symptoms of tingling/pain, muscle spasm and blood flowing around in my calfs and pooling in my feet worsened. Can Coumadin cause Muscle Pain? Muscle Pain is a known side effect of Coumadin. Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Muscle Pain is a known side effect of Coumadin. pain, muscle pain, warfarin, gerd, muscle Details: since using warfarin i have been plaued by severe muscle pains in the shoulder and neck areas and sometimes in the upper leg muscle.